Brexit, for once some facts.

[POLLY]

The WHO has published this
"
DRAFT prepared by the SAGE Working Group on COVID-19 vaccines
10 February 2021
5
Background document for the Extraordinary meeting of the Strategic Advisory Group of Experts on
Immunization (SAGE) – 08 February 2021
Pre-clinical studies
Note: The following information is derived from scientific publications. Those publications used the term “ChAdOx1-S (recombinant)” which is equivalent to AZD1222.
The efficacy of ChAdOx1-S (recombinant) was assessed in rhesus macaques. Six animals per group were vaccinated using a prime-only regimen (28 days before challenge) or a prime–boost regimen (56 and 28 days before challenge) intramuscularly with 2.5 × 1010 ChAdOx1-S (recombinant) virus particles each. As a control, six animals were vaccinated via the same route with the same dose of ChAdOx1-S (recombinant) green fluorescent protein (GFP) (one animal was vaccinated 56 and 28 days before challenge and five animals were vaccinated 28 days before challenge). No adverse events were observed after vaccination. Spike-specific antibodies were present as early as 14 days after vaccination and were significantly increased after the second immunization (two-tailed signed-rank Wilcoxon test). Endpoint IgG titres of 400–6,400 (prime) and 400–19,200 (prime–boost) were measured on the day of challenge. Virus-specific neutralizing antibodies were also significantly increased after secondary immunization (two-tailed signed-rank Wilcoxon test) and detectable in all vaccinated animals before challenge (5–40 (prime) and 10–160 (prime–boost)), whereas no virus-specific neutralizing antibodies were detected in control animals. IgM antibodies were present in the serum after vaccination on the day of the challenge in six out of six prime–boost and two out of six prime-only animals SARS-CoV-2 spike-specific T cell responses were detected on the day of challenge by IFNγ ELISpot assay after the stimulation of peripheral blood mononuclear cells with a peptide library that spanned the full length of the spike protein. No statistically significant difference in the magnitude of the response was found between the prime–boost and prime-only group (Mann–Whitney U-test, P = 0.3723). As previously reported6, vaccination with ChAdOx1-S (recombinant) resulted in the induction of neutralizing antibodies against the vaccine vector itself within 28 days of vaccination. Nonetheless, a boost vaccination with ChAdOx1-S (recombinant) resulted in a significant increase in binding and neutralizing antibodies in NHPs and an increase in the SARS-CoV-2 virus-neutralizing titre was not significantly correlated with the ChAdOx1-S (recombinant) virus-neutralizing titre (two-tailed Pearson correlation, r2 = 0.6493 P = 0.0529).
A post-vaccination SARS-CoV-2 challenge in rhesus macaques was conducted to evaluate protection and the potential for vaccine-associated enhanced respiratory disease (VAERD)[2]. Clinical disease score in monkeys was reduced, and the vaccine prevented damage to the lungs. A prime-boost regimen induced humoral immune responses. Viral loads were reduced in the lungs, but there was no reduction in viral shedding from the nose with either prime-only or prime-boost regimens. These suggest that ChAdOx1-S (recombinant) may not prevent infection nor transmission of SARS-CoV-2, but it may reduce illness. The immune responses were not skewed towards a Th2-type and there was no suggestion of enhanced disease following vaccination. Whilst a single dose induced antigen-specific antibody and T cells responses, a booster immunisation enhanced antibody

100% Bullcrap

 

[oldgroaner]

100% Bullcrap

Does this constitute a peer review.?

 

[Jesus H Christ]

100% Bullcrap

Give us a clue where you stand on Coronavirus.

 

[Zlatan]

100% Bullcrap

All his posts are. Brilliant timing.
Perhaps we could arrange a meeting between OG and Polly. Eddie Hearn might be interested... Harry Hill more appropriate.

 

[Zlatan]

Israeli drug that substantially alleviates serious Covid symptoms completes second phase trials

Trials found 90 per cent of patients who were seriously ill recovered after being treated with Allocetra

www.telegraph.co.uk

Some more positive news.

 

[oldgroaner]

All his posts are. Brilliant timing.
Perhaps we could arrange a meeting between OG and Polly. Eddie Hearn might be interested... Harry Hill more appropriate.

You've done it again haven't you? you really need to think what you are doing, better still stop this

 

[oldgroaner]

Israeli drug that substantially alleviates serious Covid symptoms completes second phase trials

Trials found 90 per cent of patients who were seriously ill recovered after being treated with Allocetra

www.telegraph.co.uk

Some more positive news.

I reported this days ago

 

[Zlatan]

You've done it again haven't you? you really need to think what you are doing, better still stop this

What about you stopping? You don't see your own little digs at all do you? Every comment I have ever made is in response to you.. Fact. Hypocrite.

 

[Zlatan]

I reported this days ago

I believe you reported this one.

New Israeli Covid drug which cured 30 cases of disease hailed by scientists as 'huge breakthrough'

The EXO-CD24 substance was developed in Tel Aviv and successfully completed its first phase of clinical trials on Friday

www.telegraph.co.uk

The drug I provided link to is Allocetra. Similar story.
It seems they have found 2 drugs quite recently. Exo cd24 and Allocetra.??? Don't believe they are same..

 

[flecc]

I believe you reported this one.

New Israeli Covid drug which cured 30 cases of disease hailed by scientists as 'huge breakthrough'

The EXO-CD24 substance was developed in Tel Aviv and successfully completed its first phase of clinical trials on Friday

www.telegraph.co.uk

The drug I provided link to is Allocetra. Similar story.
It seems they have found 2 drugs quite recently. Exo cd24 and Allocetra.??? Don't believe they are same..

They were developed at two different medical centres.

I'm a bit suspicious about them developing two successful treatments at different local centres so take both stories with a pinch of salt for now, pending evidence and peer review. Israel has a penchant for stories about their breakthroughs in science and engineering, but most disappear without trace or are seen to fail.
.

 

[Woosh]

Covid: WHO backs Oxford vaccine 'even if variants present' https://www.bbc.co.uk/news/health-56011981

it is a balanced and political judgement taking into account availability and cost.
The AZ vaccine is the only running candidate for COVAX program. WHO can't afford to use any other vaccine.
Also, despite numerous reports confirming that prime boot regimen is much better than prime only regimen, lengthening the time gap between first and second jab spreads vaccination to more people.

 

[Zlatan]

They were developed at two different medical centres.

I'm a bit suspicious about them developing two successful treatments at different local centres so take both stories with a pinch of salt for now, pending evidence and peer review. Israel has a penchant for stories about their breakthroughs in science and engineering, but most disappear without trace or are seen to fail.
.

Agreed, the stories are so similar too. or too similar so... I, d thought myself it was same drug rereported... But different teams, different hospitals and different generic drugs. (one is a cancer treatment, the other an immune inhibitor)
Time will tell.

 

[Woosh]

@vfr400 - you remember the WSB story?
I've just read that Fidelity sold all their 9.3 millions but 87 GME shares at near peak.
I do feel sorry for those redditors who still hold.

 

[oldgroaner]

What about you stopping? You don't see your own little digs at all do you? Every comment I have ever made is in response to you.. Fact. Hypocrite.

yet again? and what response of mine drew this attack?
Stop it!

 

[oldgroaner]

This is not good news for the economy

 

[oldgroaner]

Thought for the day

 

[Jesus H Christ]

it is a balanced and political judgement taking into account availability and cost.
The AZ vaccine is the only running candidate for COVAX program. WHO can't afford to use any other vaccine.
Also, despite numerous reports confirming that prime boot regimen is much better than prime only regimen, lengthening the time gap between first and second jab spreads vaccination to more people.

This is what we’ve been saying since day one, set against the background noise of people on here shouting it down.

 

[Woosh]

This is what we’ve been saying since day one, set against the background noise of people on here shouting it down.

nobody disputes the benefit of spreading the stock of vaccine to more people. However, studies show that those who had the second jab have up to 4 times more antibodies than those with single jab.
If you have 30 millions doses (roughly what we would have until end of April), would you use them on 30 millions people or 15 millions of the most vulnerable?
It's a matter of political judgement.
What we criticise is government propaganda, pushing for single jabs while discretely give second jabs to Pfizer receivers.
The US CDC said that those who are properly vaccinated do not have to quarantine if coming into contact with someone who has covid.

 

[oldgroaner]

This is what we’ve been saying since day one, set against the background noise of people on here shouting it down.

It is a compromise the gamble that might or might not pay off

 

[Zlatan]

Ursula von der Leyen says sorry over 'late' EU vaccine shambles

European commission president Ursula von der Leyen also conceded its rollout was still not 'where we want to be' in a humbling speech in Brussels.

www.dailymail.co.uk

At least she has grace to apologise.??