Easy mistake to make, I've deleted my query quoting your original.
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Brexit, for once some facts.
- Thread starter flecc
- Start date
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there is no chemical relationship between Molnupiravir (a derivative of cytidine) and Ivermectin (a macrocyclical lactone).
Molnupiravir works like a virus made for viruses. During replication, viruses accept Molnupiravir same as the real cytidine, Molnupiravir creates so many faulty mutations of the virus, effectively stops the virus killing the patient.
Ivermectin works on invertebrates chemistry, not humans, not viruses. Ivermectin has no effect on viruses such as covid.
Had Nazis not employed such awful social policies they would probably have been successful with their thousand year Third Reich. Technical, engineering and general
innovations (Road network for one) they were years ahead of Uk/USA.. Look at which
engineers went to America and put an American on the moon. Jet engines, rocket propulsion, flight control, fuel injection, weapons,... List is endless where Germans had better equipment and more advanced design. (even AK 47 borrowed many features from lessons learned by Russians being on receiving end of such weapons)
US, UK and Russians purely won on logistics. One advanced weapons system was no match for 5 (slightly) outdated ones.. (in most aspects, Tanks, planes, Submarines and machine guns they were way ahead)
Saying Nazis were "thick" is exactly opposite of what was actually going on. They made ridiculous errors. (starting Operation Barborosa before invading us was probably biggest, but that was purely Hitler. Had he left war to be fought by his generals, we, d all be speaking German now.)
Thick they were not.
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There may not be a direct chemical relationship. That doesn't mean their mode of operation isn't similar. I seem to recall reading that some scientists are hypothesizing that both of them work as protease inhibitors.
That is correct. However as with many other drugs, there can be more than one mode of operation.
I believe this is incorrect.
There are many studies out there showing the effectiveness of Ivermectin. For example, a quick search brings up a paper,
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7996102/
and in that for example, they cite other studies, and I quote from the discussion:
"Ivermectin is a popular choice of drug for treating various parasitic infections ... Moreover, ivermectin has also been explored as an endectocide for reducing malarial vectors... Recently, ivermectin has been reported for antiviral activity toward SARS-CoV-2..."
And there are now dozens and dozens of studies (including peer reviewed, double blind placebo controlled ones!) out there that show its effectiveness.
If anyone want to plough though some data, here are a couple of interesting links:
https://ivmmeta.com/
https://covid19criticalcare.com/ivermectin-in-covid-19/epidemiologic-analyses-on-covid19-and-ivermectin/
And I've mentioned this before - before anyone pipes up with "so if its effective, why aren't governments using it?" etc
Well remember that if an existing treatment is available (via a repurposed existing drug), then EUA's (emergency use authorisations) cannot be issued. Therefore any government that wishes to roll out currently unapproved vaccinations for whatever reasons, CANNOT admit to the effectiveness of ANY existing drug.
And also bear in mind that SOME governments around the world HAVE been using Ivermectin, and others (such as India) are now suing the WHO for trying to suppress its use. But of course, things like this don't seem to be reported in our mainstream media, so most people won't know unless they follow non-MSM journalistic sources.
I agree with your overall argument, but I think that when Rommel had failed to get the oil fields in Libya and Persia, he basically had to go East. Remember the only energy resources they had was coal and lignite . Their chemists were smart but not magicians
Yep, agreed.
Again though Germans showed great ingenuity producing oil and petro chemicals from coal. Another area they were leading the way with. Not the actions of "thick" chemists.
Thank you for proving the old sayingNo, OG, I, m afraid I don't see the parallels. We haven't had a Crystalnacht, we still have a democracy, but without a viable 2nd party. We aren't looking for extra living room, we aren't expelling Jews and closing down Jewish businesses. We aren't embarking on secret arms development to avoid scrutiny, we aren't brain washing our youth...
Perhaps you, d like to expand on your claim.
Really
What is fascism?
Fascism is a political ideology that's actually pretty difficult to define.www.livescience.com
Our Government has its faults. It is not a fascist regime at all.
"The only thing we learn from History
is that we determinedly ignore how it could possibly happen again"
Half of the nation was brainwashed into Brexit, including you, and the last couple of days was their version of "burning of the books"
The Jews are not the target this time, just the poor
And lets face it the cull of the elderly population in care homes.
These Tory politicians are either evil or as we saw willing stooges, and a danger to all
Time for you to stop being an apologist for them
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Joe, I don't know much about antivirals so I can't have a sensible discussion with you on that.
However, I know that a lot of antivirals do more harm than good. Molnupiravir is still going through trials at the moment. It's not the first time this government jumps the gun and licence an experimental drug. To its credit, it is only offered to patients in pretty dire situations where the patient will likely die from covid like that lady on TV in treatment for her cancer.
On Ivermectin, I am pretty convinced that using it to treat covid is not a good idea. It's like using antibiotics to treat a viral infection.
quote:
Ivermectin has been shown to inhibit the replication of SARS-CoV-2 in cell cultures.13 However, pharmacokinetic and pharmacodynamic studies suggest that achieving the plasma concentrations necessary for the antiviral efficacy detected in vitro would require administration of doses up to 100-fold higher than those approved for use in humans.14,15 Even though ivermectin appears to accumulate in the lung tissue, predicted systemic plasma and lung tissue concentrations are much lower than 2 µM, the half-maximal inhibitory concentration (IC50) against SARS-CoV-2 in vitro.16-19 Subcutaneous administration of ivermectin 400 µg/kg had no effect on SARS-CoV-2 viral loads in hamsters. However, there was a reduction in olfactory deficit (measured using a food-finding test) and a reduction in the interleukin (IL)-6:IL-10 ratio in lung tissues.20
Since the last revision of this section of the Guidelines, the results of several randomized trials and retrospective cohort studies of ivermectin use in patients with COVID-19 have been published in peer-reviewed journals or have been made available as manuscripts ahead of peer review. Some clinical studies showed no benefits or worsening of disease after ivermectin use,21-24 whereas others reported shorter time to resolution of disease manifestations that were attributed to COVID-19,25-27 greater reduction in inflammatory marker levels,26 shorter time to viral clearance,21 or lower mortality rates in patients who received ivermectin than in patients who received comparator drugs or placebo.21,27
edit: link
Antivirals, Including Antibody Products | COVID-19 Treatment Guidelines
These sections summarize the data on antiviral agents, including remdesivir, ritonavir-boosted nirmatrelvir, and anti-SARS-CoV-2 monoclonal antibodies.
www.covid19treatmentguidelines.nih.gov
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And our Wurzel Gummage and the Zombie cabinet are all highly educated, even Quasi coathanger famed for his interview technique.
They are Fascist through and through.
And actually Germany would still have been beaten by the Russians
Well that means they are very much cheaper than the average Tory MP, but you voted for them, and they cocked up the NHS
I could agree with you OG but then I, d be wrong too.
As for your comment Russia could have won war without US... Utterly ridiculous. Shows your ignorance of subject.
It was a close run thing as it was. Without second front (French) Germany would have obliterated Russia,especially so without the arms and food UK carried to Russia from Uncle Sam. Not publicised much but even with all the help over 2 million Russians starved to death,even with the aid.
ru.usembassy.gov
How would Russia have coped without this aid, especially so facing the entire Nazi war machine on its own. It wouldn't have.
As for your comment Russia could have won war without US... Utterly ridiculous. Shows your ignorance of subject.
It was a close run thing as it was. Without second front (French) Germany would have obliterated Russia,especially so without the arms and food UK carried to Russia from Uncle Sam. Not publicised much but even with all the help over 2 million Russians starved to death,even with the aid.
World War II Allies: U.S. Lend-Lease to the Soviet Union, 1941-1945
Even before the United States entered World War II in December 1941, America sent arms and equipment to the Soviet Union to help it defeat the Nazi
ru.usembassy.gov
How would Russia have coped without this aid, especially so facing the entire Nazi war machine on its own. It wouldn't have.
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We appear to have some of the best educated cabinet members ever. PhDs in double-speak all round.
The education secretary, Nadhim Zahawi, has accepted the government committed errors in its attempt to save the former minister Owen Paterson from suspension, but denied the debacle called into question the prime minister’s judgment.
If it doesn't call into question the PM's judgement, does that mean the PM didn't make the decisions? Or that the PM's errors are entirely normal and acceptable?
The education secretary, Nadhim Zahawi, has accepted the government committed errors in its attempt to save the former minister Owen Paterson from suspension, but denied the debacle called into question the prime minister’s judgment.
If it doesn't call into question the PM's judgement, does that mean the PM didn't make the decisions? Or that the PM's errors are entirely normal and acceptable?
it seems to me that OP knew already what he would do if BJ does not come to his rescue. Let's wait for the result of the by-election. I reckon Labour would take the seat from the tories.
Read a vox pop type of report and the constituents didn't appear to have any sympathy for him.
It is a big majority to overturn - but let us hope Labour do so.
If tory central office parachute a suitably high profile candidate and drop enough cabinet ministers in, that should seal it for Labour.
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That's why he was appointed Secretary of State for Education in September. By today's Tory standards he was ideally qualified.
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Has anyone checked availability in Florida?
www.theguardian.com
UK supplies of fake tan threatened by shortage of key ingredient
Cosmetics producers run short of solvent also used in makeup, skin creams and beauty products
www.theguardian.com
It would simply have taken longerI could agree with you OG but then I, d be wrong too.
As for your comment Russia could have won war without US... Utterly ridiculous. Shows your ignorance of subject.
It was a close run thing as it was. Without second front (French) Germany would have obliterated Russia,especially so without the arms and food UK carried to Russia from Uncle Sam. Not publicised much but even with all the help over 2 million Russians starved to death,even with the aid.
World War II Allies: U.S. Lend-Lease to the Soviet Union, 1941-1945
Even before the United States entered World War II in December 1941, America sent arms and equipment to the Soviet Union to help it defeat the Nazi
View attachment 44647
How would Russia have coped without this aid, especially so facing the entire Nazi war machine on its own. It wouldn't have.
"Lend-lease supplied the USSR with 1.9% of all artillery, 7% of all tanks, 13% of all aircraft, 5.4% of transport in 1943, 19% transport in 1944 and 32.8% in 1945. Lend-lease deliveries amounted to 4% of Russia's wartime production. "
I see that Johnson is absolutely set on digging the largest hole in Europe:
Johnson will not declare Spanish holiday in MPs’ register, says No 10
Decision means he does not have to detail value of gift relating to stay at Goldsmith family villa
Johnson will not declare Spanish holiday in MPs’ register, says No 10
Decision means he does not have to detail value of gift relating to stay at Goldsmith family villa
They didn't have longer. And your figures don't take into account situation before Russia moved production east.The aid bought them the required time. They rebuilt all major industry out of range of Nazis and utilised the Shermans etc (and more importantly the food) to hold off the Germans whilst their own industry could replace losses.. As war progressed production grew and grew but without the initial help Russia would have been in German hands.
The defeat of Nazis was even with UK /Canada/Australia/NZ/US and Russia a very close run thing. Another few months would have seen Germany with certainly Jet fighters and probably the Atomic bomb.
Without the continual bombing by UK and US and without the distraction of War in France Russia would have stood absolutely no chance on its own. Their technology was years behind Germans. Its actually quite a stupid assertion to make.
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The scale of the USSR's own tank production almost defied belief.
That they moved their factories - out of range of Germany - then built huge numbers. Also, one problem the Germans made for themselves was sheer quality. The German tanks were so much more sophisticated and beautifully finished. But one shell could destroy a German tank just as easily as it could a Russian one. Attrition became the name of the game.