Brexit, for once some facts.

flecc

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I hope no-one starts a war...

UK military chiefs self-isolate after head of army catches Covid
Defence secretary and heads of Royal Navy and RAF all isolating after Gen Sir Nick Carter’s positive Covid test

or even a shindig in the Black Sea.
It's the perfect time for war, without them we'd probably win much quicker.

Remember the first world war maxim, heros led by donkeys.
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flecc

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In the case of the man-madeness of Covid-19, we are not actually discussing whether or not it was. But whether or not we believe is was. The reality is binary - it either was, or was not, for any given definition of being man-made. Everything else is perception and attempting to discern the reality.
Not quite so clear cut. Woosh with his appropriate knowledge has examined the chemistry of Covid-19 and determined known factors that point to it having a likelyhood of being man made, as opposed to naturally occurring through multi animal transmission.

That gives a positive start point, to be followed by suspicion caused by such things as the Chinese resistance to outside investigation and how easily and effectively they dealt with the infection. These point strongly to them having advanced pre-knowledge, a second positive point.
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Woosh

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In another part of my life, I am involved with many who have health issues. A very significant proportion count their illness back to some infection or other - the following being commonly mentioned:

Cytomegalovirus (CMV)
Epstein-Barr virus (EBV)
Hepatitis B virus (HBV))
Hepatitis C virus (HCV)
Herpes simplex virus (HSV)
Varicella Zoster virus

And many go on to suffer Chronic fatigue syndrome, aka myalgic encephalomyelitis (ME), or other long-term illness - including autoimmune disorders. Suffering often continuing for many years. Deaths from such disorders are often missed. If someone has been ill for years, and then they get a final disease or their organs give up, autoimmunity, CFS/ME, etc., might well not appear on their death certificates. Or if they do appear, they just provide some sort of context and are not really considered as causes.

The numbers who have died must be huge. (And I am excluding the considerable numbers who suffer mental health issues and then do things which result in their deaths - not just suicide but also things that they would not normally have done.)

(There are also non-viral disease like Lime disease.)

The evidence for these connections tends to be relatively poor - after all, if you had influenza ten years ago, would you put down symptoms that started a year or two ago and have worsened very slowly down to that dose of influenza? If you stayed at home for a few days and then appeared to recover, would you have any proof of which virus you suffered?

My step-father had bronchitis one winter - and could never again smell or taste properly. I'm quite sure that never went on any records hence was not recorded in statistics. Whether it was the bronchitis or the antibiotics which caused it can never be determined.
Covid may be linked to lethal blood clots.
That seems to be significant.
 

oyster

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Not quite so clear cut. Woosh with his appropriate knowledge has examined the chemistry of Covid-19 and determined known factors that point to it having a likelyhood of being man made, as opposed to naturally occurring through multi animal transmission.

That gives a positive start point, to be followed by suspicion caused by such things as the Chinese resistance to outside investigation and how easily and effectively they dealt with the infection. These point strongly to them having advanced pre-knowledge, a second positive point.
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But those points only adjust your suspicions. You perception. Not the reality.

The suspicion about a sequence of amino acids has been widely dismissed as interesting but in no way proof. There are other viruses with the same or similar sequences.
 
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flecc

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But the other things I mentioned have been around for decades, centuries, quite possibly millennia.
I don't deny their importance, but the obvious response is, why haven't they previously been at the root of pandemics for decades and centuries when we've had so many vectors prior to Covid-19?
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oldgroaner

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But those points only adjust your suspicions. You perception. Not the reality.

The suspicion about a sequence of amino acids has been widely dismissed as interesting but in no way proof. Thre are other viruses with the same or similar sequences.
But they seem to lack the ability to become more deadly and transmissible at the rate this one does.
As if several variants already exist and are being released at intervals
 
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oyster

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But they seem to lack the ability to become more deadly and transmissible at the rate this one does.
As if several variants already exist and are being released at intervals
There's no issue with speculation and examination of evidence. There is an issue when it goes off half-cocked and converts these into accepted "truths".
 

oyster

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I don't deny their importance, but the obvious response is, why haven't they previously been at the root of pandemics for decades and centuries when we've had so many vectors prior to Covid-19?
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Transmissivity seems to be top of the list. Plus variable responses - some of us seeming to cope and rid ourselves when others don't - though whether that is genetic, dietary, other diseases, etc., who knows?
 
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flecc

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There's no issue with speculation and examination of evidence. There is an issue when it goes off half-cocked and converts these into accepted "truths".
I'm not claiming any truths, just not ignoring the positive pointers.
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oyster

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I'm not claiming any truths, just not ignoring the positive pointers.
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I wasn't pointing at any of the posters here - but you don't have to go far to find people who claim they are recipients of amazing information, the one truth. not available to anyone else. (Even if plastered over half the internet.)

And that is without getting into religion!
 

Woosh

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But those points only adjust your suspicions. You perception. Not the reality.

The suspicion about a sequence of amino acids has been widely dismissed as interesting but in no way proof. There are other viruses with the same or similar sequences.
The authors of the paper below show the way that SARS-COV-2 can be developed/made in 6 months.

"As a coronavirus, SARS-CoV-2 differs significantly from other respiratory and/or zoonotic viruses: it attacks multiple organs; it is capable of undergoing a long period of asymptomatic infection; it is highly transmissible and significantly lethal in high-risk populations; it is well-adapted to humans since the very start of its emergence1 ; it is highly efficient in binding the human ACE2 receptor (hACE2), the affinity of which is greater than that associated with the ACE2 of any other potential host."

http://gnews-media-offload.s3.amazonaws.com/wp-content/uploads/2020/09/14100542/The_Yan_Report-.pdf
 

flecc

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I wasn't pointing at any of the posters here - but you don't have to go far to find people who claim they are recipients of amazing information, the one truth.
One doesn't even need to leave this forum, since we have two members at least who are convinced Covid-19 doesn't exist except as a conspiracy by the authorities to control us.

They are members Chainring and POLLY.

In fairness there is a conspiracy by the authorities to control us. They just keep the majority of the people too poor to do anything but work and be obedient.
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flecc

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"As a coronavirus, SARS-CoV-2 differs significantly from other respiratory and/or zoonotic viruses: it attacks multiple organs
For a number of reasons I've always believed that HIV/AIDS was more likely to have been man made in the USA than evolve in Africa, in part since it also has this unusual characteristic and causes combinations of diseases previously unknown.

I saw this at first hand in one of the first to die from AIDS, the doctors at Kings completely baffled by the combinations of what he was suffering. This immediately followed his return from living for a while in San Francisco where AIDS was already established.

And back then we were also spun the multi-animal transmission story to account for it.
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Nev

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3: Apparently Hancock can't spot a CCTV camera obviously visible on the ceiling
I couldn't understand this when the story first came out. I have not seen the video just the picture on the front page of the Sun, but in the video Hancock can be seen looking out into the corridor to make sure no one was going to come along and interrupt them. So I was wondering how could they both have not noticed an obvious CCTV camera on the ceiling that we all will have seen in shops etc.

The answer apparently was that the camera was built into a smoke detector and so unless you knew what you were looking at you would have no idea you were being watched.

Alan Johnson who was a health secretary under Labour some time ago said yesterday that in his time there (as far as he was aware) no health minister had CCTV cameras in their private offices.

Someone else said yesterday that the only person who had the legal authority to sanction hidden cameras in a Ministers office was the Prime Minister, no idea if this is the case or not, but could raise a whole host of questions if true.
 

oldgroaner

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I couldn't understand this when the story first came out. I have not seen the video just the picture on the front page of the Sun, but in the video Hancock can be seen looking out into the corridor to make sure no one was going to come along and interrupt them. So I was wondering how could they both have not noticed an obvious CCTV camera on the ceiling that we all will have seen in shops etc.

The answer apparently was that the camera was built into a smoke detector and so unless you knew what you were looking at you would have no idea you were being watched.

Alan Johnson who was a health secretary under Labour some time ago said yesterday that in his time there (as far as he was aware) no health minister had CCTV cameras in their private offices.

Someone else said yesterday that the only person who had the legal authority to sanction hidden cameras in a Ministers office was the Prime Minister, no idea if this is the case or not, but could raise a whole host of questions if true.
While that is possible Gove seems more likely.
Somehow he always reminds me of Himmler
 
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flecc

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Oct 25, 2006
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Someone else said yesterday that the only person who had the legal authority to sanction hidden cameras in a Ministers office was the Prime Minister, no idea if this is the case or not, but could raise a whole host of questions if true.
Like was it David Cameron, Theresa May or Boris Johnson.

Or even Nick Clegg made fall guy from when he shared the job in the Coalition government. ;)

I fear we'll never know.
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POLLY

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Aug 10, 2016
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The authors of the paper below show the way that SARS-COV-2 can be developed/made in 6 months.

"As a coronavirus, SARS-CoV-2 differs significantly from other respiratory and/or zoonotic viruses: it attacks multiple organs; it is capable of undergoing a long period of asymptomatic infection; it is highly transmissible and significantly lethal in high-risk populations; it is well-adapted to humans since the very start of its emergence1 ; it is highly efficient in binding the human ACE2 receptor (hACE2), the affinity of which is greater than that associated with the ACE2 of any other potential host."

http://gnews-media-offload.s3.amazonaws.com/wp-content/uploads/2020/09/14100542/The_Yan_Report-.pdf
Brainwashing Bullshit
 
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POLLY

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I couldn't understand this when the story first came out. I have not seen the video just the picture on the front page of the Sun, but in the video Hancock can be seen looking out into the corridor to make sure no one was going to come along and interrupt them. So I was wondering how could they both have not noticed an obvious CCTV camera on the ceiling that we all will have seen in shops etc.

The answer apparently was that the camera was built into a smoke detector and so unless you knew what you were looking at you would have no idea you were being watched.

Alan Johnson who was a health secretary under Labour some time ago said yesterday that in his time there (as far as he was aware) no health minister had CCTV cameras in their private offices.

Someone else said yesterday that the only person who had the legal authority to sanction hidden cameras in a Ministers office was the Prime Minister, no idea if this is the case or not, but could raise a whole host of questions if true.
Brainwashing Bullshit
 
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Woosh

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Brainwashing Bullshit
this is a bit of conspiracy theory for you:

QUOTE from that paper:

"To engineer and create a human-targeting coronavirus, they would have to pick a bat coronavirus as the template/backbone. This can be conveniently done because many research labs have been actively collecting bat coronaviruses over the past two decades32,33,70,72,81-85. However, this template virus ideally should not be one from Dr. Zhengli Shi’s collections, considering that she is widely known to have been engaged in gain-of-function studies on coronaviruses [her work was paid for by American government]. Therefore, ZC45 and/or ZXC21, novel bat coronaviruses discovered and owned by [Chinese] military laboratories33, would be suitable as the template/backbone. It is also possible that these military laboratories had discovered other closely related viruses from the same location and kept some unpublished. Therefore, the actual template could be ZC45, or ZXC21, or a close relative of them.
The postulated pathway described below would be the same regardless of which one of the three was the actual template. Once they have chosen a template virus, they would first need to engineer, through molecular cloning, the Spike protein so that it can bind hACE2.
The concept and cloning techniques involved in this manipulation have been well-documented in the literature44-46,84,86. With almost no risk of failing, the template bat virus could then be converted to a coronavirus that can bind hACE2 and infect humans44-46.
Second, they would use molecular cloning to introduce a furin-cleavage site at the S1/S2 junction of Spike. This manipulation, based on known knowledge60,61,65, would likely produce a strain of coronavirus that is a more infectious and pathogenic.
Third, they would produce an ORF1b gene construct. The ORF1b gene encodes the polyprotein Orf1b, which is processed post-translationally to produce individual viral proteins: RNA-dependent RNA polymerase (RdRp), helicase, guanidine-N7 methyltransferase, uridylate-specific endoribonuclease, and 2’-O-methyltransferase.
All of these proteins are parts of the replication machinery of the virus. Among them, the RdRp protein is the most crucial one and is highly conserved among coronaviruses. Importantly, Dr. Zhengli Shi’s laboratory uses a PCR protocol, which amplifies a particular fragment of the RdRp gene, as their primary method to detect the presence of coronaviruses in raw samples (bat fecal swap, feces, etc). As a result of this practice, the Shi group has documented the sequence information of this short segment of RdRp for all coronaviruses that they have successfully detected and/or collected. Here, the genetic manipulation is less demanding or complicated because Orf1b is conserved and likely Orf1b from any β coronavirus would be competent enough to do the work. However, we believe that they would want to introduce a particular Orf1b into the virus for one of the two possible reasons:
1. Since many phylogenetic analyses categorize coronaviruses based on the sequence similarity of the RdRp gene only18,31,35,83,87, having a different RdRp in the genome therefore could ensure that SARS-CoV-2 and ZC45/ZXC21 are separated into different groups/sub-lineages in phylogenetic studies. Choosing an RdRp gene, however, is convenient because the short RdRp segment sequence has been recorded for all coronaviruses ever collected/detected. Their final choice was the RdRp sequence from bat coronavirus RaBtCoV/4991, which was discovered in 2013. For RaBtCoV/4991, the only information ever published wasthe sequence of its short RdRp segment83, while neither its full genomic sequence nor virus isolation were ever reported. After amplifying the RdRp segment (or the whole ORF1b gene) of RaBatCoV/4991, they would have then used it for subsequent assembly and creation of the genome of SARS-CoV-2. Small changes in the RdRp 17 sequence could either be introduced at the beginning (through DNA synthesis) or be generated via passages later on. On a separate track, when they were engaged in the fabrication of the RaTG13 sequence, they could have started with the short RdRp segment of RaBtCoV/4991 without introducing any changes to its sequence, resulting in a 100% nucleotide sequence identity between the two viruses on this short RdRp segment83. This RaTG13 virus could then be claimed to have been discovered back in 2013.
2. The RdRp protein from RaBatCoV/4991 is unique in that it is superior than RdRp from any other β coronavirus for developing antiviral drugs.
RdRp has no homologs in human cells, which makes this essential viral enzyme a highly desirable target for antiviral development.
As an example, Remedesivir, which is currently undergoing clinical trials, targets RdRp. When creating a novel and human-targeting virus, they would be interested in developing the antidote as well. Even though drug discovery like this may not be easily achieved, it is reasonable for them to intentionally incorporate a RdRp that is more amenable for antiviral drug development.
Fourth, they would use reverse genetics to assemble the gene fragments of spike, ORF1b, and the rest of the template ZC45 into a cDNA version of the viral genome. They would then carry out in vitro transcription to obtain the viral RNA genome. Transfection of the RNA genome into cells would allow the recovery of live and infectious viruses with the desired artificial genome.
Fifth, they would carry out characterization and optimization of the virus strain(s) to improve the fitness, infectivity, and overall adaptation using serial passage in vivo. One or several viral strains that meet certain criteria would then be obtained as the final product(s). "
 
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