Taken from Oxford Astra Zeneca quote this morning.
Brexit, for once some facts.
- Thread starter flecc
- Start date
Taken from Oxford Astra Zeneca quote this morning.
A certain wry amusement over the way they are ignoring the basis of the licence for the vaccine and changing the time between doses.
I am NOT saying they are wrong to do this. But almost every day I see someone being mistreated by a doctor who insists some aspect of a medicine's licence must be adhered to however well-known that it isn't important.
One example, vitamin B12 injections in the UK have licences which state they are to be used firstly every other day until symptoms are relieved/no further improvement, secondly every 8 or 12 weeks (depending on an arcane difference).
Doctors throughout the land misinterpret every other day as, at best, three times a week, but often twice a week. Or however many they can fit in regardless the licence terms.
Then absolutely refuse to offer them more frequently than every 12 weeks - both in cases where the licence says 8 weeks, and in other cases where patients simply cannot survive 12 weeks. So a mix of rigid interpretation and ignorance.
This vaccine case shows that intelligence might be needed to maximise the quality of treatment and numbers treated. Hopefully hard evidence will come about and the terms then get updated.
Is it a case of needs must and all that.
I, d guess other issue is since virus is mutating at some point vaccine will need to change, but they already have millions of this one??? Use it before it's obsolete??
They can stick some in my arm, the sooner the better.??
How do they authorise yearly flu jab? It's a different strain every year but they don't go through this process each year, do they?
If virus mutates and they adjust vaccine accordingly (some bloke was on other day saying its quite possible) do they have to run trials on altered vaccine???
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Absolutely - needs must and there is even some evidence it might be better to not follow the original licence terms.
I said right from the beginning that, as soon as a vaccine has been rolled out to enough people to prove basic safety, I will have it (when offered). Those on whom it was tested at least have a major support effort available should they suffer. The greater public don't. Hence my wish to see a reasonable start before submitting.
Of course there are risks. There could be long-term effects but that is a risk I am willing to accept.
I think they do test the flu vaccine each year. But according to a well-defined and repeated process.
So will they be able to modify Covid vaccines without going through trials process?
You seem rather more knowledgeable with these things..
There is a virologist in TCD .Luke O Neill,is his name, He has been on the button with every toss and turn of this pandemic over the last year, . His view, which I would have confidence in is that any of the three vaccines is well capable of handling any of the minor mutations which occur. If tweaking is required ,then it can be achieved. My analogy for this forum is that you don't need to get a new a type approval document when you change the saddle on an ebike.
No - they test the flu vaccines each year. With trials. As I understand. It is just that the whole set up can be put on a calendar and, although dates might be missed, the plan just needs some elastic in it. What they need to do will be more or less identical every year.
This was very different.
Yep, I think that's the general opinion short term... But in a year? 3 years? I believe numbers talked about are 20 or so mutations monthly... From what I, ve read a new, or modified, vaccine will be needed in future.
??? Might need one for current strain in London????
How quick can process be.. We had Astra Zeneca vaccine about 10 months ago..??? Trials, procedures were longer than development?? (but still amazingly quick)
They should all be applauded.
I, m just wondering how long from identifying need for a vaccine to getting one in people's arms can be shortened to safely. (this will happen again)
Virology is not my thing, so I asked my daughter,fresh from her masters in genetics. The best way of looking at viruses is as a factory with incredibly poor quality control. When a virus actually gets into a cell ..in itself a relatively improbable event, only made likely by incredibly large numbers of viruses and cells,it takes over . It then produces vast numbers of copies if itself, until it has exausted the capacity of the cell. Now the vast majority of the copies are defective,and only something like 5 to 10% of the copies are identical with the original. All the rest are mutations. Again the vast majority of these mutations are totally defective, basically inert blobs of chemical. But occasionally , just very occasionally a mutation is potentially infective, and maybe capable of attaching to a more susceptible or more plentiful cell. ..and so the cycle continues.
The reason that viruses mutate so readily, is because they don't have the built in error detection and correction of DNA. Mutations are a daily occurrence
It is also the reason why it was necessary to stamp down very hard on any initial outbreak, to reduce the probability of viable mutations,and why the Herd Immunity concept was so very counter productive
Amusing level of detail in the FT
Paul@paulj71
·
15h
This is the level of detail rules of origin get down to. I am a former Dover Customs Officer on an export freight clearance team. I currently have a headache trying to get my head around it.
Oh Dear, oh dear
Paul@paulj71
·
15h
This is the level of detail rules of origin get down to. I am a former Dover Customs Officer on an export freight clearance team. I currently have a headache trying to get my head around it.
Oh Dear, oh dear
In the Independent
"
The public has delivered an overwhelming thumbs-down to the Brexit trade deal, just 17 per cent saying they think it will be “good” for the country.
Even among Leave voters, only 27 per cent told a survey that the deal was a success – and only one in three Conservative supporters said it was.
So the Leave campaign scored 1/3rd of a success eh?
"
The public has delivered an overwhelming thumbs-down to the Brexit trade deal, just 17 per cent saying they think it will be “good” for the country.
Even among Leave voters, only 27 per cent told a survey that the deal was a success – and only one in three Conservative supporters said it was.
So the Leave campaign scored 1/3rd of a success eh?
Will that be after the next big asteroid impact destroys Europe, or because the EU became the USE?
What funny ideas you have,
By the way I couldn't find any reference to the EU rejecting the deal on the Squid website.
But wouldn't it be fun if they did?
How sweet
Cash and Francois to carry on fighting for Brexit
Way to go Penfold, you may need help from Danger mouse though
Cash and Francois to carry on fighting for Brexit
Way to go Penfold, you may need help from Danger mouse though
It's clear enough, but no customs officer will have the necessary information to accurately check compliance, especially when the non-originating parts extend beyond the eyes. Dolls hair for example.
.
Certainly that would be true when a consignment in a container goes bye, but for those eagle eyed accountant types who look at purchasing manifests and then BOMs ,it can be clear. What customs can do is work on a guilty until proven innocent rule. .They assume that full duty is payable and the importer / exporter has to prove them wrong. So the onus comes back on the manufacturer..and is just added cost.
Aye, aye, cap'n.Amusing level of detail in the FT
Paul@paulj71
·
15h
This is the level of detail rules of origin get down to. I am a former Dover Customs Officer on an export freight clearance team. I currently have a headache trying to get my head around it.
Oh Dear, oh dear
How on earth can you determine the ex-works price of a doll's eyes? How much is a doll without eyes worth? Not much, I'd guess, unless an old and beloved one owned by an individual.
Is the price of a doll's eyes different to the incremental value they add to the doll?
And shouldn't it start with "Dolls' eyes..." because the eyes of all dolls fall into the same category as all dolls...
What has happened is that the 27 embassies of the EU countries have signed off pro tem , and their word is good until either , their national governments votes no ..in the qualified majority calculation, or the EU parliament votes no .. Neither of which is anyway probable. Than from your side the UK Parliament will vote yes.
So the FTA slim deal starts running from Friday.
Eventually.. sooner rather than later ,the cracks will show, and the Remainders and hardliners in the UK will continue to day ,I told you so. But the EU will sail on regardless
they don't have to check on the day.
HMRC can do a CIT compliance check anytime they want.
You have to prove that you are innocent.
CIT: customs and international trade.
Compliance checks: customs and international trade - CC/FS1g
This factsheet is about compliance checks into customs and international trade matters.
I haven't checked but I suspect it starts from 23:00 GMT Thursday?
Oyster, perhaps you never worked in manufacturing?. But the answer is clear. Every part has a purchase price, an installation cost ( labour) and an overheads cost . The Bill of Materials BOM , includes all these . So the ex works cost includes all these,and is no different for a wheel barrow or a Rolls Royce. . Now it gets complicated when the rubies in the dashboard clock,are at a different rate than the Connolly Leather.Aye, aye, cap'n.
How on earth can you determine the ex-works price of a doll's eyes? How much is a doll without eyes worth? Not much, I'd guess, unless an old and beloved one owned by an individual.
Is the price of a doll's eyes different to the incremental value they add to the doll?
And shouldn't it start with "Dolls' eyes..." because the eyes of all dolls fall into the same category as all dolls...