I use an electric bike rather than an ordinary one as my various physical problems meant that my non-electric bike was getting less and less use, and when I DID get out on it, it was very hard work, particularly up small hills.
I have one plastic leg, and the so-called 'good' leg has various problems, too. These make walking painful, and although I can push quite hard with my prosthetic foot, it's obviously not as strong as a proper leg. That, plus the almost inevitable gain in weight (most amputees know all about this!) meant that electric was a logical step.
I bought a Wisper in June 2010, and have done many hundreds of miles since - I attend all my hospital appointments by bike.
Others with leg problems will probably follow my purchasing example and go for a bike WITH a throttle, rather than the throttle-less Panasonic-type bikes. I tried the latter, and was highly impressed by their build quality and power, but the absence of the throttle, almost indispensable for those lacking leg power to start off on hills, swayed me to the Wisper.
If you've got 'normal' legs but other problems, then the Kalkhoff might be the bike for you, but obviously do try them first, and not just on the flat.
Allen, bka, Wisper 905se, 2010.