A USA perspective on the Moderna vaccine - and stretching it out:
Initial supplies of COVID-19 vaccines are obviously limited, even as drugmakers ramp up production, so governments are looking for ways to stretch their stocks. For Moderna’s mRNA-1273, that could mean reducing the dosing strength.
The U.S. government is considering halving the dose of Moderna’s COVID-19 vaccine, Operation Warp Speed chief Moncef Slaoui told CBS’ Face the Nation Sunday. The vaccine task force is in talks with Moderna and the FDA about implementing the idea, he said.
“We know that, for the Moderna vaccine, giving half of the dose to people between the ages of 18 and 55, two doses [at] half the dose … we know it induces identical immune response” to the currently authorized dose, Slaoui added.
https://www.fiercepharma.com/pharma/feds-consider-half-dose-moderna-covid-19-vaccine-as-u-k-spaces-out-pfizer-astrazeneca-shots
If unconditionally true, the phrase "identical immune response" does rather suggest that precise dose is a movable feast.
Initial supplies of COVID-19 vaccines are obviously limited, even as drugmakers ramp up production, so governments are looking for ways to stretch their stocks. For Moderna’s mRNA-1273, that could mean reducing the dosing strength.
The U.S. government is considering halving the dose of Moderna’s COVID-19 vaccine, Operation Warp Speed chief Moncef Slaoui told CBS’ Face the Nation Sunday. The vaccine task force is in talks with Moderna and the FDA about implementing the idea, he said.
“We know that, for the Moderna vaccine, giving half of the dose to people between the ages of 18 and 55, two doses [at] half the dose … we know it induces identical immune response” to the currently authorized dose, Slaoui added.
https://www.fiercepharma.com/pharma/feds-consider-half-dose-moderna-covid-19-vaccine-as-u-k-spaces-out-pfizer-astrazeneca-shots
If unconditionally true, the phrase "identical immune response" does rather suggest that precise dose is a movable feast.