Yes. You will get 33% more speed and climbing torque, but there's a downside. A hub-motor becomes ineffecient wgen it runs at less than 50% of its max speed. Say you have a motor that can reach 20 mph, but it's restricted to 15 mph. It will be inefficient at full throttle below 10 mph. When you go up to 48v, it will be inefficient below 13 mph. The further you go below 50% max speed, the worse the efficiency, so the higher the chance of burning out the motor and the more battery you waste.
If it's just hill-climbing you want, it might be better to just increase the current.
If you're thinking of changing the battery and controller, it would be better to get the right kit in the first place and convert a normal bike rather than try and adapt an electric bike.