I have been riding the synapse neo se for a few month now, and what I can tell you is this: If the bike is a means of transportation, closing distances without sweating but also having a vehicle to go to have fun explicitely not using support, the synapse neo is a great deal. Soft offroad feels great, also that you can face a curbstone opposed to a racing bike where you have to worry about flats in that situation does stand out on a gravel bike configuration.
It does have custom tire dimensions, as it has custom nuts for securing the tires which can be refitted for obvious reasons, but if you want to emphasize having a bike to be a sports tool to focus on your sportive capability, maybe the Orbea may be the right choice.
I am happy with the Cannondale as I use it to expand my range in the city taking the place of a scooter while providing me the control to be a sports vehicle if I choose so. I use max support so traffic lights do not bother me, but I can still push my limits if I want to which is most of the time. I am very glad about my choice in the urban area, and I can say that the climbs or wind I encounter, I can completely tackle them effordlessly if I choose to ride with support.
I would prefere to have a flatbar instead the racing cockpit which I do not see a use to me at least, but the version with flatbar has worse components so I stuck to the neo se.
But to sum it up, I love this bike, I am very happy about the Bosch drive as well. While many people are concerned about the weight, I can tell you from experience that the only time it bothers me is, when I am carrying it up several stories into my appartement. Otherwise, with or without support this bike feels very agile and nimble. But this is subjective, of course if you want to create your own oppinion you should take it for a ride and compare it to its adversaries.
Addition: The saddle is probably the most personal part since it is the most important interface of the bike, when you buy it it should be one of the first parts that has to be adjusted to you.