People run those up to 72v. I've never heard of any ebike motor with insulation breakdown. There's been a few that completely burned because too much power was used at too low speed. You should see what people are doing with tiny motors on Endless-sphere. They fill their little 250w Bafang hub-motors with oil and then run them with 20 amps at 72v. Did you know that you can now get a 50 amp 72v controller for a BBSHD? Don't tell Soundwave though.
https://electricbike-blog.com/2016/12/28/kill-yourself-50-faster-with-2x-the-power-e-r-t-s-72v-50amp-3000w-ext-bbshd-controller/
I've personally run 36v motors at 64v using 48v controllers. Nothing blew except the tyres from the wheel-spin.
Basically, you can run any e-bike motor at any voltage. The only consequence is that you have to be mindful of the efficiency. Increasing the voltage increases the motor speed and moves the efficiency curve up the RPM band, so you can't use such high power at low rpm for long.
It doesn't make much sense to increase the voltage much on a crank-drive because it increases the crank speed to faster than what you pedal and reduces the efficiency at normal pedal speed. You'd be much better off increasing the current for more torque.