And in the trade and since I almost always mend a puncture with the wheel in, and could never have completed all needed in the time available if I'd taken wheels out.
Still flip the bike over of course, releasing the brake cable outer if a rim brake is fitted. Then the tyre can be taken off on one side, the tube freed and pumped to locate the puncture. There's plenty of room to pass the tube around rotated with the wheel, and with a slow puncture a water bowl can easily be used to locate the air leak. Once located, the tube can be laid across the tyre with the puncture point at the convenient height for repair, so no back breaking bending down needed.
Then refit is just as easy. Doing it this way has the advantage of having the wheel held firmly for you and it does leave all the settings undisturbed on a rear wheel, gear cable, chain etc.
.